The home page
A section-by-section guide to the home page of alzheimers.ephemerisx.com, from the drug table to the decision timeline.
The home page of alzheimers.ephemerisx.com reads from top to bottom, broad to deep: every approved drug first, then the anti-amyloid antibodies, then each of their decisions.
Header and count tiles#
The page opens with the title Alzheimer's drugs at the FDA and four tiles:
- FDA-approved Alzheimer's drugs
- Anti-amyloid antibodies
- Anti-amyloid decisions traced
- Applications pending: always Not published by FDA, with a link down to Pending.
Under the tiles, a note says whether every decision has a complete record loaded. If not, it says how many do and that the rest show what is missing.
Every FDA-approved Alzheimer's drug#
A table with one row per drug, grouped by what the label says the drug is for:
- Brain imaging (PET): amyloid and tau
- Agitation associated with dementia due to Alzheimer's disease
- Treatment of Alzheimer's disease
- Treatment of dementia of the Alzheimer's type
- No current FDA label
| Column | Shows |
|---|---|
| Drug | Brand name. Anti-amyloid antibodies have an In depth ↓ link to their card. |
| What the label says it is for | The indication, quoted from the label, with a link such as FDA label, effective <date> ↗. If the brand has no label of its own, the link says so and points to a same-ingredient generic's label. |
| First approved | The first approval of the application. It can predate the Alzheimer's indication. |
| Status | ● Marketed (at least one product not discontinued) or ○ Discontinued (the row is greyed). |
| FDA applications | Each application number, linked to Drugs@FDA. |
| Generic applications | How many generic applications reference it. |
The fine print under the table explains the sources and ends with the date the data was fetched.
Anti-amyloid antibodies, in depth#
One card per antibody. Each card has:
- Products: brand, BLA number, an Approved or Refused pill, the pathway and date, and the latest action.
- FDA decisions: a dated list. Each item has a pill, a link to its decision entry and its Basis.
- ARIA: where the agency's position on ARIA started or changed, and where it stands, each with a status pill, date, quote and citation. The block ends with Every ARIA position, all drugs →.
Events the FDA has not recorded are stated as such, for example “not in the FDA record · checked <date>”.
Decision timeline#
| Column | Shows |
|---|---|
| Date | Action date. |
| Drug | The drug, linked to its decision entry. A decision whose documents are not all loaded is tagged Record incomplete. |
| Decision | Approved or refused. |
| Pathway | For example accelerated approval, traditional approval, or complete response. |
| Basis | What the decision rested on. |
| Advisory committee | The meeting date and headline vote (for example Q1: x yes · y no · z uncertain), Not referred, or Not mentioned. |
| Confirmatory | The confirmatory trial required and its completion date, None (no postmarketing requirement in the letter), or Not applicable for refusals. |
On phones the table becomes a stack of cards.
Five regulatory questions#
Five cards, one per thread, each with its question and a Follow the thread → link to the threads page.
Pending#
Explains why the site does not list applications under review, and what it watches instead. See Pending applications.
Also relevant, not in the drug list#
Items that matter for Alzheimer's but are not drugs in the list, for example a blood test device. They are “Listed only: no entry.”